Top 10 Best Cannabis Strains for Anxiety

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Anxiety disorders affect roughly 8% of the world’s population (almost 1 in 13 according to the World Health Organization). While used as a blanket term for multiple disorders, anxiety can range from slight stress to being completely crippling and everything in between. As an alternative to more mainstream therapy, medicinal marijuana has been used in the treatment of anxiety for ages. The best weed strains for anxiety are going to be those where the CBD levels are equal to or higher than THC levels.

CBD, or cannabidiol, is a non-psychoactive element in marijuana that’s widely considered one of the most therapeutic substances available. CBD won’t get you high, but being in equal to or higher quantities than THC levels will counteract the psychoactive qualities of THC and provide a more tranquil, therapeutic high. Here we provide our top picks for the best weed for anxiety and depression:


Known for being one of the highest CBD strains on the market, ACDC is at the top of our list as a best strain of weed for anxiety. The CBD levels in ACDC can be as high as 19% and it has a CBD-to-THC ratio of 1:20! Due to this high ratio, there’s very little psychoactivity with this strain; it’s a Sativa-dominant strain and highly-rated for reducing anxiety. Though it produces a euphoria, patients are warned about the possible side effect of a dry mouth after use.


Also known for having a low THC content, Cannatonic ranks on our list as a best type of weed for anxiety. With a CBD level as high as 17%, Cannatonic’s characterized by being uplifting and relaxing. The low THC levels mean there are little-to-no psychoactive effects. In addition to reducing anxiety, Cannatonic holds clout in the medical marijuana community for also treating inflammation in patients.


Not everyone can take a hit and veg out. For people needing to stay mentally focused while medicinally treating their anxiety, Trident is ideal. As one of the choices considered the best weed for anxiety, Trident has CBD levels in the 12% range with THC levels under 6%. This strain has been known to produce mild psychoactivity, but frequent users say it’s more cerebral. Patients who react more to THC psychoactivity may want to consider another strain, but we find Trident to be an excellent choice.

Valentine X

A variant of ACDC, Valentine X ranks on our list as a 50/50 hybrid strain that has a CBD-to-THC ratio of 25:1. Valentine X is described as producing deep relaxation. This may not be the strain for you to take if you need to focus, but it’s excellent for treating anxiety. An added bonus for Valentine X is that it’s commonly used to treat inflammation, fatigue, and seizures, as well. Its name derives from Saint Valentine, the patron saint not only of lovers but also of epilepsy. Clever, right?

One To One

One To One, as the name suggests, features a 1:1 ratio of CBD to THC. This strain is less psychoactive (balanced out by the cannabinoids) and very therapeutic. Another strain that’s useful for those who need to stay active and focused, One To One is another fantastic choice to add to the list of best weed for anxiety because it calms the mind and body while keeping you alert. For those suffering from anxiety at work, this is a potential choice that allows for maintained productivity.

Granddaddy Purple

Granddaddy Purple, or GDP, is a hybrid strain made from two indica strains (Purple Urkle and Big Bud). This strain gives patients physical relaxation, not only relieving symptoms of anxiety but also providing relief from pain, insomnia, and stress. Its tension-relieving qualities make this a strain you may want to use at home when you don’t have to be performing a job. Granddaddy Purple has a large bud structure and a grape scent.

Girl Scout Cookies

Girl Scout Cookies, known commonly as GSC, are named for the toasted cookie scent it gives off as it’s burned. A strong strain, GSC users report feeling the effects almost instantly. As one of the best strains of weed for anxiety and depression, GSC induces a euphoria many patients find draws them into social situations. After the initial cerebral effects wear off, this strain puts the body into a relaxed state. As a medicinal strain, GSC is used to treat anxiety, depression, pain, nausea, and PTSD.


Harlequin makes our list as a hybrid marijuana strain. CBD levels in this strain range from 6-15% while THC levels are in the 4-10% range. This gives the strain a CBD-to-THC ratio of 5:2.  Recommended to be taken in the afternoon, Harlequin gives users an uplifting feeling and helps battle anxiety.

Northern Lights

One of the most popular indica-dominant strains, Northern Lights is extremely relaxing. If you find that THC works best for your anxiety, indicas are typically the way to go. Sometimes called “two hit and quit,” Northern Lights is known for making patients super drowsy albeit happy. Some say they use it to increase focus and creativity, but the drowsiness level comes on quickly, so that may be short lived. Northern Lights is an excellent strain for those suffering from anxiety, but its drowsiness-inducing qualities lend it to be a choice for treatment of insomnia, too.

Strawberry Cough

Last on our list, though certainly not least, Strawberry Cough is a strain known for treating social anxiety. Smelling of strawberries, and providing patients with a sensation leading up to coughing as the smoke expands in the lungs, the name of this strain isn’t hard to understand. Strawberry Cough gives a cerebral high, providing a euphoric state. This strain is also great for managing stress levels.

Wrapping Up

There’s no single strain of marijuana that’s the best for anxiety. Everyone is different and therefore, each bud will effect every person differently. When looking to treat anxiety, experiment with different strains and see what works best for you. GreenMed is happy to help you find these strains and deliver them right to your door! GreenMed — Cannabis Simplified!


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Laws regarding recreational marijuana are constantly changing! Always consult your local authorities or attorney for professional advice!


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